Πρόσθετοι δείκτες αθηρωμάτωσης σε παιδιά με δυσλιπιδαιμία

Abstract

Aim: To evaluate the importance of small, dense LDL-C (sdLDL-C), urotensin II (U-II) andtotal antibodies against oxidized LDL-C (ox-LDL-Abs) in children with dyslipidemia.Methods: The study population consisted of 648 children (325 males), 4-18 years old, 316with LDL-C ≥130mg/dl and 332 with LDL-C <130mg/dl (controls).Results: SdLDL-C levels were significantly higher in children with dyslipidemia. Daily plantsterols’ consumption (2g) resulted in a significant decrease of sdLDL-C levels. Children underhypolipidemic medication had significantly higher sdLDL-C levels than controls. SdLDL-Clevels were not correlated with sex, age or BMI. U-II levels were significantly lower indyslipidemic children compared to controls, in girls and in overweight/obese children; whilethere was no correlation with age. LDL-C, TC, non-HDL-C, TGs and apoB had a significantnegative effect on U-II levels; while HDL-C and apoA-I had a significant positive effect.There were no differences of levels of total ox-LDL-Abs between dyslipidemic children andcontrols. Finally, girls had significantly higher ox-LDL-Abs levels than boys.Conclusions: a) sdLDL-C levels could be a useful tool in the evaluation of children withdyslipidemia and their response to therapeutic measures, b) More studies are needed for theevaluation of U-II and c) Total ox-LDL-Abs do not offer any useful information.