The effect of growth factor-enriched agents in the healing of colon after resection of experimentally induced colonic endometriosis: an experimental rat model

Abstract

Study objective: To examine the potential beneficial effect of platelet rich plasma (PRP) and fibrin sealant (TISSEEL; Baxter Healthcare Corporation, Deerfield, IL) on bowel wound healing after shaving of an experimentally induced endometriotic lesion. Design: Single-blind randomized experimental study (Canadian Task Force classification I). Setting: Certified animal research facility. Animals: Thirty female Sprague-Dawley rats. Interventions: Experimental colonic endometriosis was induced by transplanting endometrial tissue to all animals (first surgery). Thirty rats were then randomized to 1 of 3 groups according to treatment: PRP (group I, n = 10), fibrin sealant (group II, n = 10), or no agent (group III, n = 10) was applied after shaving of the endometriotic nodule (second surgery). Measurements and Main Results: Colonic endometriosis was successfully induced in all subjects. Four days following the second surgery, the animals were euthanized, and microscopic evaluation was perfor ...
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DOI
10.12681/eadd/45740
Handle URL
http://hdl.handle.net/10442/hedi/45740
ND
45740
Alternative title
Η πιθανή ευεργετική δράση αυξητικών παραγόντων στην επούλωση πειραματικά δημιουργηθείσας και εκταμθείσας ενδομητριωσικής εστίας στο παχύ έντερο επιμύων
Author
Prodromidou, Anastasia (Father's name: Ioannis)
Date
2019
Degree Grantor
National and Kapodistrian University of Athens
Committee members
Βάος Γεώργιος
Περρέα Δέσποινα
Δημητρούλης Δημήτριος
Παυλάκη Αικατερίνη
Νικητέας Νικόλαος
Σχίζας Δημήτριος
Παπαλάμπρος Αλέξανδρος - Λουκάς
Discipline
Medical and Health Sciences
Health Sciences
Keywords
Endometriosis; Autologous growth factors; Colorectal endometriosis; Shaving; Platelet rich plasma; Fibrin sealant
Country
Greece
Language
Greek
Description
142 σ., im., tbls., fig.
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