Συγκριτική μελέτη της επίδρασης διαφόρων μεθόδων ή τεχνικών στο χρόνο σύγκλεισης της μυριγγοτομής σε πειραματόζωα

Abstract

Objective: To compare Radiofrequency Myringotomy (RFM) with Laser Assisted Tympanostomy (LAT), as well as the effectiveness of Mitomycin C (MC) on the above techniques on rabbits. Method: Bilateral myringotomies were performed under general anesthesia on 40 rabbits. LAT was performed on 20 animals (40 ears) and RFM on the remaining 20 animals (40 ears). MC (0.3 mg/ml) pledgets were applied to the right ears and saline pledgets to the left ears. Animals were monitored weekly using otomicroscopy until myringotomy closure. Kaplan?Meier survival techniques were used to compare myringotomy patency times. Results: The mean patency times of the saline?treated ears were: 1.85 weeks (95% Confidence Interval: 1.556?2.144weeks) for the LAT group, and 1.70 weeks (95% Confidence Interval: 1.494?1.906weeks) for the RFM group. This difference was not significant (p>0.5). MC application significantly prolonged mean patency time (p<0.0001) in both LAT and RFM groups. The mean patency times in the MC treated ears were: 5.45 weeks (95% Confidence Interval: 5.226?5.674weeks) for the LAT group, and 5.55 weeks (95% Confidence Interval: 5.285?5.815weeks) for the RFM group. This difference was not significant (p>0.5). Conclusion: There is no significant difference in myringotomy patency times between LAT and RFM techniques on rabbits, while MC significantly prolongs the patency rate of both techniques