Περίληψη
ALL HISTOLOGICAL SPECIMENS OF PANCREAS OF NEWBORN INFANTS, WHOSE INDIRECT BILIRUBIN HAD EXCEEDED 15 MG% DURING THEIR LIFE, WERE REVIEWED FOR THE LAST SIX YEARS AT THE ST. SOPHIES'S CHILDREN'S HOSPITAL. THE HISTOLOGICAL SPECIMENS OF PANCREAS OF 35 NEWBORN INFANTS WITHOUT JAUNDICE, TAKEN AT RANDOM, WHOSE DEATH WAS DUE, IN THE MAJORITY OF CASES, TO RESPIRATORY CAUSES (HYALINE MEMBRANE DISEASE, BRONCHOPNEUMONIA ETC.) OR TO CONGENITAL ABNORMALITIES WERE USED AS CONTROLS. IN TOTAL 33 JAUNDICED NEWBORNS (14 PREMATURE AND 19 FULLTERM INFANTS) WERE STUDIED AND COMPARED TO 35 CONTROLS (12 PREMATURE AND 23 FULLTERM NEWBORN INFANTS). IN 4 BABIES THE JAUNDICE WAS DUE TO RHESUS INCOMPATIBILITY, IN 8 TO ABO INCOMPATIBILITY, IN 13 TO G-6-PD DEFICIENCY AND IN 8 THE ETIOLOGY OF THE JAUNDICE COULD NOT BE ASCERTAINED. THE LANGERHANS ISLETS WERE FOUND TO BE HYPERPLASTIC NOT ONLY IN THE 4 INFANTS WHOSE SEVERE JAUNDICE WAS DUE TO RHESUS INCOMPATIBILITY, BUT, TO A LESSER DEGREE, IN THE MAJORIT ...
ALL HISTOLOGICAL SPECIMENS OF PANCREAS OF NEWBORN INFANTS, WHOSE INDIRECT BILIRUBIN HAD EXCEEDED 15 MG% DURING THEIR LIFE, WERE REVIEWED FOR THE LAST SIX YEARS AT THE ST. SOPHIES'S CHILDREN'S HOSPITAL. THE HISTOLOGICAL SPECIMENS OF PANCREAS OF 35 NEWBORN INFANTS WITHOUT JAUNDICE, TAKEN AT RANDOM, WHOSE DEATH WAS DUE, IN THE MAJORITY OF CASES, TO RESPIRATORY CAUSES (HYALINE MEMBRANE DISEASE, BRONCHOPNEUMONIA ETC.) OR TO CONGENITAL ABNORMALITIES WERE USED AS CONTROLS. IN TOTAL 33 JAUNDICED NEWBORNS (14 PREMATURE AND 19 FULLTERM INFANTS) WERE STUDIED AND COMPARED TO 35 CONTROLS (12 PREMATURE AND 23 FULLTERM NEWBORN INFANTS). IN 4 BABIES THE JAUNDICE WAS DUE TO RHESUS INCOMPATIBILITY, IN 8 TO ABO INCOMPATIBILITY, IN 13 TO G-6-PD DEFICIENCY AND IN 8 THE ETIOLOGY OF THE JAUNDICE COULD NOT BE ASCERTAINED. THE LANGERHANS ISLETS WERE FOUND TO BE HYPERPLASTIC NOT ONLY IN THE 4 INFANTS WHOSE SEVERE JAUNDICE WAS DUE TO RHESUS INCOMPATIBILITY, BUT, TO A LESSER DEGREE, IN THE MAJORITY OF OTHER JAUNDICED INFANTS. THE SURFACE OF THE LANGERHANS ISLETS WAS WELL CORRELATED WITH THE HIGHEST BILIRUBIN LEVEL IN ALL GROUPS OF JAUNDICED INFANTS. THE PATHOGENESIS OF THE OBSERVED HYPERPLASIA IS ALSO DISCUSSED. THE FOLLOWING ARE CONSIDERED AS PROBABLE ETIOLOGIC FACTORS: 1) RAISED CIRCULATING LEVELS OF GLUTATHIONE, LIBERATED FROMRED BLOOD CELLS DURING HEMOLYSIS, BEING RESPONSIBLE FOR THE DESTRUCTION OF ATLEAST A PART OF CIRCULATING INSULIN, 2) PLACENTAL HYPERPLASIA CAUSING AN INCREASED DESTRUCTION OF INSULIN, THEREBY (ABSTRACT TRUNCATED)
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