Application of the technology of liposomes and dendrimers in the design and study of new chimeric nanosystems for the delivery of the anticancer drug doxorubicin

Abstract

A plethora of drug molecules with significant biological activity, both in vitro and in vivo, have been found to be inactive during clinical trials. Nanotechnology seems to be the multiscientific field that will permit the clinical application of many of the above molecules. The formulation of a drug molecule with nanocarriers may alter the ADME (Administration, bioDistribution, Metabolism, Exertion) profile of the drug to a large extent. A new approach for nanocarrier design is the development of chimeric drug delivery systems that result from the combination of nanoparticles. The main representative category of chimeric drug delivery systems is liposomal locked-in dendrimers (LLDs) that result from the combination of liposomes and dendrimers. LLDs have been successfully developed in the past but there is a gap in the literature concerning the interactions of the parts of the final nanocarrier; information that is necessary for the rational design of such nanosystems. In the present s ...
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DOI
10.12681/eadd/36495
Handle URL
http://hdl.handle.net/10442/hedi/36495
ND
36495
Alternative title
Εφαρμογή της τεχνολογίας των λιποσωμάτων και δενδριμερών στο σχεδιασμό και τη μελέτη νέων χιμαιρικών νανοσυστημάτων μεταφοράς του αντικαρκινικού φαρμάκου δοξορουβικίνη
Author
Gardikis, Konstantinos (Father's name: Rizos-Emmanouil)
Date
2010
Degree Grantor
National and Kapodistrian University of Athens
Committee members
Δεμέτζος Κωνσταντίνος
Βύρας Κυριάκος
Σκρέττα Μαρία
Αντιμησιάρη Σοφία
Τσοτίνης Ανδρέας
Μαυρομούστακος Θωμάς
Δρακούλης Νικόλαος
Discipline
Natural SciencesChemical Sciences
Medical and Health SciencesHealth Sciences
Keywords
Nanotechnology; Liposomes; Dendrimers; Chimeric nanaosystems; Doxorubicin; Cancer; Liposomal locked in dendrimers
Country
Greece
Language
Greek
Description
363 σ., im., tbls., fig., ch.
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