Application of the technology of liposomes and dendrimers in the design and study of new chimeric nanosystems for the delivery of the anticancer drug doxorubicin
Abstract
A plethora of drug molecules with significant biological activity, both in vitro and in vivo, have been found to be inactive during clinical trials. Nanotechnology seems to be the multiscientific field that will permit the clinical application of many of the above molecules. The formulation of a drug molecule with nanocarriers may alter the ADME (Administration, bioDistribution, Metabolism, Exertion) profile of the drug to a large extent. A new approach for nanocarrier design is the development of chimeric drug delivery systems that result from the combination of nanoparticles. The main representative category of chimeric drug delivery systems is liposomal locked-in dendrimers (LLDs) that result from the combination of liposomes and dendrimers. LLDs have been successfully developed in the past but there is a gap in the literature concerning the interactions of the parts of the final nanocarrier; information that is necessary for the rational design of such nanosystems. In the present s ...
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