Επίδραση της χρήσεως των αναλόγων των προσταγλανδινών ( λατανοπρόστης, τραβοπρόστης και μπιματοπρόστης) στο κεντρικό πάχος του κερατοειδούς ασθενών με χρόνιο γλαύκωμα

Abstract

Purpose: To evaluate the effect of prostaglandin analogues on the central corneal thickness (CCT) of patients with chronic open-angle glaucoma (COAG). Methods: 129 eyes participated in this study. Of these, 108 eyes were treated with prostaglandin analogues (latanoprost, travoprost and bimatoprost), while 21 eyes treated with b-blockers were used as controls. CCT was measured before treatment and at three-month intervals. Results: A slight but significant increase in CCT was recorded in the bimatoprost and latanoprost groups. Treatment with bimatoprost produced a constant increase (1, 85- 8, 83 μm) in CCT at all time points of the study. The CCT rise found in the latanoprost group was significant for the first year. Treatment with travoprost did not affect CCT. Conclusions: The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly.