INVESTIGATION OF THE PEPTIDE BACKBONE FOLDINGS. SYNTHESIS AND CONFORMATIONAL ANALYSIS OF ANALOGUES OF THE CENTRAL SEQUENCE OF ANGIOTENSIN II. UV-VIS AND NMR SPECTROSCOPIES

Abstract

SPECIFIC SIDE CHAIN-SIDE CHAIN INTERACTIONS BETWEEN TRP AND NVA(NIC+) HAVE BEENSUCCESSFULLY VISUALIZED BY APPLYING CHARGE TRANSFER MARKERS IN THE LRF MOLECULE (P-GLU-HIS-TRP-SER-TYR-GLY- LEU-ARG-PRO-GLY-NH2) AND ANALOGUES OF ITS CENTRALSEQUENCE, ACCORDING TO THE PROBABILITY OF B-TURN FORMATION. ON THE OTHER HAND,SIDE CHAIN-SIDE CHAIN INTERACITONS BETWEEN TYR4 AND HIS6 IN ANGIOTENSIN II, ASP-ARG-VAL-TYR-VAL-HIS-PRO- PHE, HAVE BEEN STUDIED BY THE COMBINED USE OF C.D., I.R. AND NMR EXPERIMENTS. WITH THE AIM OF FORMULATING A RATHER SIMPLE WAY TO EVALUATE LONG DISTANCE INTERACTIONS OF THIS KIND IN PEPTIDES WITH MORE OR LESS EXTENDED BACKBONE CONFORMATIONS WE HAVE SYNTHESIZED THE FOLLOWING SERIES OF TRIPEPTIDES: AC-TRP-X-NVA(NIC+)-NH2,CL- WHERE X=VAL, LEU, ALA, GLY. ALL THE FOUR ANALOGUES SHOWED A CHARACTERISTIC CHARGE TRANSFER BAND AND THE DIFFERENCES IN THE INTENSITY REVEALED AN INCREASED SIDE CHAIN-SIDE CHAIN INTERACTION IN THE ORDER OF GLY<ALA<LEU<VAL, I.E. AS THE FOLDING OF THE BACKBONE ...
show more

All items in National Archive of Phd theses are protected by copyright.

DOI
10.12681/eadd/1036
Handle URL
http://hdl.handle.net/10442/hedi/1036
ND
1036
Alternative title
ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΔΙΠΛΩΣΗΣ ΤΟΥ ΠΕΠΤΙΔΙΚΟΥ ΣΚΕΛΕΤΟΥ. ΣΥΝΘΕΣΗ ΚΑΙ ΑΝΑΛΥΣΗ ΤΗΣ ΔΙΑΜΟΡΦΩΣΗΣ ΑΝΑΛΟΓΩΝ ΤΟΥ ΚΕΝΤΡΙΚΟΥ ΤΜΗΜΑΤΟΣ ΤΗΣ ΑΓΓΕΙΟΤΕΝΣΙΝΗΣ ΙΙ. ΦΑΣΜΑΤΟΣΚΟΠΙΕΣ UV-VIS ΚΑΙ NMR
Author
Bairaktari, Eleni (Father's name: Th.)
Date
1988
Degree Grantor
University of Ioannina
Committee members
ΣΑΚΑΡΕΛΛΟΣ ΚΩΝΣΤΑΝΤΙΝΟΣ
ΣΑΚΑΡΕΛΛΟΥ-ΔΑΙΤΣΙΩΤΟΥ ΜΑΡΙΑ
ΠΑΠΑΜΙΧΑΗΛ ΕΜΜΑΝΟΥΗΛ
ΚΟΡΔΟΠΑΤΗΣ ΠΑΥΛΟΣ
ΤΖΟΥΓΚΡΑΚΗ ΧΡΥΣΗ
Discipline
Natural Sciences
Chemical Sciences
Keywords
ANGITENSIN II ANALOGUES; BACKBONE FOLDING IN PEPTIDES; CHARGE TRANSFER COMPLEXES IN PEPTIDES; NMR spectroscopy; Nuclear magnetic resonance spectroscopy; PEPTIDE SYNTHESIS IN SOLID AND LIQUID PHASE; PROTEIN CONFORMATION; SELECTIVE NICOTINAMIDATION IN PEPTIDES; Ultraviolet-visible spectroscopy; UV-Vis spectroscopy
Country
Greece
Language
Greek
Description
-1
Usage statistics
VIEWS
Concern the unique Ph.D. Thesis' views for the period 07/2018 - 07/2023.
Source: Google Analytics.
ONLINE READER
Concern the online reader's opening for the period 07/2018 - 07/2023.
Source: Google Analytics.
DOWNLOADS
Concern all downloads of this Ph.D. Thesis' digital file.
Source: National Archive of Ph.D. Theses.
USERS
Concern all registered users of National Archive of Ph.D. Theses who have interacted with this Ph.D. Thesis. Mostly, it concerns downloads.
Source: National Archive of Ph.D. Theses.
Related items (based on users' visits)